As the characters' addictions worsen, their lives begin to unravel. Harry and Marion's relationship deteriorates, and they become increasingly paranoid and isolated. Sara's addiction to the diet pills leads to a series of disturbing and surreal experiences, while Tyrone's involvement in the heroin trade puts him in danger.

Seorang janda kesepian yang terobsesi ingin tampil di acara TV dan mulai menyalahgunakan pil diet agar muat mengenakan gaun merah favoritnya. Harry Goldfarb (Jared Leto):

Ellen Burstyn, Jared Leto, Jennifer Connelly, and Marlon Wayans.

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