The USA ISO (NTSC-U) is the standard North American release. It features English voice acting (mostly gibberish with English text/UI) and runs at 60Hz. It is compatible with Wii consoles from North America and can be played on European (PAL) consoles if the console is soft-modded or region-free.
The modding scene is small but active. Here are the best mods for the USA version: rabbids go home wii iso usa