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KBI-092 targets the 5-HT6 receptor, a receptor almost exclusively expressed in the central nervous system (CNS). By antagonizing this receptor, the drug modulates neural circuits that regulate appetite and energy expenditure. Unlike GLP-1 receptor agonists (e.g., semaglutide) which signal satiety via the gut-brain axis and often cause gastrointestinal side effects, 5-HT6 antagonists are believed to reduce food intake through central pathways in the brain, potentially offering distinct efficacy or tolerability advantages. To help me produce the correct essay for

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