For basic telemetry, yes. For critical license validation, no. Adobe has shifted to "heartbeat" check-ins that require occasional success.
Given the pitfalls of the hosts file method, what are the legitimate alternatives for managing or affording Adobe software? Adobe Hosts File Block List
Adobe is well aware of the Hosts file block list. In fact, internal Adobe security engineers have publicly stated (on Reddit and developer forums) that they consider the Hosts file to be a "trivial, legacy bypass that poses no real threat to our licensing revenue." For basic telemetry, yes
Adobe’s cloud architecture, certificate pinning, and always-online features have rendered the hosts file ineffective for piracy. Attempting to use it today leads to frustration, security vulnerabilities, and legal risk. Given the pitfalls of the hosts file method,
Paste the entries at the bottom of the file in the format: 0.0.0.0 ://name.com .